Alright, I think I might have found a solution to the problem that some of us are having with CH Products Control Manager after the Windows 10 update. The issue that I myself was having was that after downloading a profile to the stick, the buttons that allowed me to switch between direct mode, mapped mode and off mode would grey out, and the stick would become unresponsive. Sometimes this was resolved after numerous reboots, but then only until the next profile download.
Using the instructions found here I've been able to successfully switch profiles a number of times without encountering the problem. Here's the steps:
You need to prevent your computer from saving information to boot faster upon shutdown (you need to turn off fast startup in windows) so that it treats the controllers the same whether you cold boot or restart.
1. Click the start button and type "CONTROL PANEL", then choose Hardware and Sound then Power options. On the left side click "Choose what the power Buttons do". Now click "Change settings that are currently unavailable". Lastly UNcheck "Turn on fast startup (recommended)"
2. Now when you boot from cold boot or a restart it will treat the controller the same way.
3. Boot/reboot the computer. When it comes up DO NOT DO anything related to games or control manager loading scripts. You must open Control Center, or Control manager and wait for about 2-3 minutes until you hear the last chirp of the USB being recognized. Once that last chirp happens you can then load scripts or change whatever. If you do not wait for the last chirp (2-3 minutes) and you try to manage your controllers then you must reboot and start over.
4. Instead of manually opening control center upon startup. You can add the CMStart.exe (CH startup program for the 5 sec delay) shortcut to your SHELL:STARTUP folder.
Here's to hoping it holds!