Any reason why you don't run full screen mode?
If you haven't already, try disabling "Post Effects". This is only for testing purposes. Suspect here is "Super Sampling" especially; it can be a real killer to some systems. If disabling Post Effects cures the problem, you could later try to enable them again, but disable the Super Sampling part, and see if it still works.
All I can say is that this is how I run the game. My system is more powerful than yours, both CPU, GPU, and probably memory too. Most people do run Post Effects, but I'm not sure if they use the Super Sampling part of that all of the time. They maybe have more powerful systems than yours, too. In any case, it might be worth a try to disable the Post Effects just for testing purposes....it's easy to turn back on later if it doesn't make any difference.
Re Full Screen Mode: I ran on full screen earlier too, but there was a specific reason I turned it off to get rid of certain problems; unfortunatly I don't know what exectly was the reason for this.... anyhow, no prob to do a test with full screen mode again for the testflight...
And yes, the post effects I planned anyhow to turn off for my next test run, together with a significant reduction of the light sources and see then if the issue still occurs at the same point in game. As the last flight I did is easy to reproduce I will do exactly the same flight and see how system behaves then....